tetradecanedioate (c14-dc) to 3-hydroxydecanoate

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.220
Position:
151879761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
14.386
Reference Allele:
G
-log10(P):
-106.371
MAF:
0.318
Beta (Num):
0.010
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.12[1], 13[2], 14[3]

Ratio Explanation:

Elevated tetradecanedioate (omega-oxidation) relative to 3-hydroxydecanoate (beta-oxidation intermediate) suggests a shift away from beta-oxidation, potentially influenced by THEM4's role in mitochondrial lipid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SLCO1B1 function can lead to elevated total bilirubin, triglycerides, MCH, and MCV.4[1], 15[2], 16[3] A shift in fatty acid metabolism, indicated by the ratio and potentially influenced by THEM4, can also impact lipid profiles and red blood cell indices.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data