tetradecanedioate (c14-dc) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.144
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
8.663
Reference Allele:
G
-log10(P):
-39.921
MAF:
0.176
Beta (Num):
0.032
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs4149026

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.131
Position:
21315415
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
-9.611
Reference Allele:
A
-log10(P):
-48.687
MAF:
0.314
Beta (Num):
-0.124
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
54
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 LST3 SLCO1B3

Region: rs4149056

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.501
Position:
21331549
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
29.326
Reference Allele:
T
-log10(P):
-433.619
MAF:
0.155
Beta (Num):
0.506
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.005
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect a shift in fatty acid metabolism, where decreased SLCO1B1 function affects hepatic processes, potentially altering fatty acid oxidation pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the hepatic transport of bile acids and cholesterol, contributing to cholesterol supersaturation in bile, a key factor in cholelithiasis and associated lipoprotein metabolism disorders.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data