tetradecanedioate (c14-dc) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.484
Position:
21331549
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
27.346
Reference Allele:
T
-log10(P):
-377.447
MAF:
0.155
Beta (Num):
0.506
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.022
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

**Numerator Pathway(s):** Fatty acid omega-oxidation.7[1], 8[2]

Denominator Metabolite Explanation:

**Denominator Pathway(s):** Fatty Acid Metabolism.9[1], 10[2]

Ratio Explanation:

**Ratio Interpretation:** An increase in the ratio of tetradecanedioate to 10-nonadecenoate may indicate upregulated omega-oxidation of fatty acids (numerator) relative to the metabolism or transport of long-chain fatty acids (denominator), potentially influenced by CYP4A11 activity.

Ratio Evidence:

**metabolites related through biology**

Gene Ratio Phenotype Relationship:

The association of the ratio with coronary atherosclerosis may be driven by CYP4A11. Polymorphisms in CYP4A11 are linked to coronary artery disease, potentially through its role in metabolizing arachidonic acid to 20-HETE, a modulator of cardiovascular homeostasis.11[1], 12[2], 13[3]

Phenotype Driver:

**Gene-centric:CYP4A11**

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data