tetradecanedioate (c14-dc) to myristate (14:0)

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
12
Beta (Ratio):
0.494
Position:
21331549
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
29.343
Reference Allele:
T
-log10(P):
-434.109
MAF:
0.155
Beta (Num):
0.506
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.013
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid synthesis and metabolism.6[1]

Ratio Explanation:

This ratio reflects the rate of omega-oxidation of myristate to tetradecanedioate, a process catalyzed by CYP4A11.7[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4A11 activity could decrease myristate omega-oxidation, affecting downstream signaling molecules like 20-HETE, potentially linking to hypertension and coronary atherosclerosis, a phenotype also associated with SLCO1B1 variants through altered lipid metabolism.3[1], 8[2]

Phenotype Driver:

Gene-centric:CYP4A11

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data