tetradecanedioate (c14-dc) to caprate (10:0)

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of caprate (10:0)
Metabolite Accession: GCST90200428
Name: caprate (10:0)
Hmdb Id: HMDB0000511
Super Pathway: NA
Sub Pathway: NA
Inchikey: GHVNFZFCNZKVNT

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.537
Position:
21331549
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
27.613
Reference Allele:
T
-log10(P):
-384.776
MAF:
0.155
Beta (Num):
0.506
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.031
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.

Denominator Metabolite Explanation:

Fatty acid metabolism.

Ratio Explanation:

Reduced SLCO1B1 function may impair hepatic uptake of both tetradecanedioate and caprate, though their direct transport by OATP1B1 is not explicitly confirmed.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Decreased SLCO1B1 function is linked to higher levels of circulating substances it transports, like bilirubin and statins, which are associated with phenotypes including hyperbilirubinemia, altered drug responses, and potentially cardiovascular effects like arrhythmias and atherosclerosis due to downstream metabolic disturbances.2[1], 8[2], 9[3], 10[4], 11[5], 12[6], 13[7], 14[8], 15[9], 16[10], 17[11], 18[12]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data