tetradecanedioate (c14-dc) to pentadecanoate (15:0)

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.495
Position:
21331549
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
26.936
Reference Allele:
T
-log10(P):
-366.283
MAF:
0.155
Beta (Num):
0.506
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.012
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.3[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.4[1]

Ratio Explanation:

An elevated ratio may indicate increased omega-oxidation of fatty acids (tetradecanedioate) relative to the availability or transport of pentadecanoate, potentially influenced by SLCO1B1 activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can alter lipid levels, including LDL cholesterol5[1], 6[2]. This dyslipidemia is a primary risk factor for coronary atherosclerosis and can contribute to cardiac arrhythmias.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data