hexadecanedioate (c16-dc) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.149
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
8.345
Reference Allele:
G
-log10(P):
-37.184
MAF:
0.176
Beta (Num):
0.037
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs4149056

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.511
Position:
21331549
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
27.922
Reference Allele:
T
-log10(P):
-393.375
MAF:
0.155
Beta (Num):
0.516
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.005
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

Region: rs77420750

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.121
Position:
15979744
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.157
Reference Allele:
C
-log10(P):
-35.607
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.026
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 3[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, reduction pathway.10[1], 11[2]

Ratio Explanation:

The ratio may reflect a shift between fatty acid omega-oxidation and beta-oxidation, where increased CYP4F2 activity elevates hexadecanedioate while 5-dodecenoate metabolism is altered.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Elevated hexadecanedioate, driven by CYP4F2 activity, is causally linked to increased blood pressure and is associated with a higher risk of myocardial infarction and ischemic heart disease.8[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data