hexadecanedioate (c16-dc) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.138
Position:
15979744
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-9.163
Reference Allele:
C
-log10(P):
-44.430
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.043
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio of hexadecanedioate to 10-nonadecenoate may reflect altered fatty acid metabolism, where decreased CYP4F2 activity leads to changes in downstream fatty acid products.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity due to the V433M variant is linked to decreased production of 20-HETE and altered vitamin K metabolism, which are associated with an increased risk of ischemic heart disease and coronary atherosclerosis.12[1], 13[2], 14[3] Changes in fatty acid metabolism, reflected by the ratio, might also influence red blood cell membrane composition (MCV) and liver function (bilirubin).15[4], 16[5]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data