hexadecanedioate (c16-dc) to eicosenoate (20:1)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.147
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.948
Reference Allele:
C
-log10(P):
-42.467
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.052
SE (Den):
0.017
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation, Dicarboxylic acid metabolism.8[1], 9[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Fatty acid metabolism.10[1], 11[2]

Ratio Explanation:

A higher ratio may reflect decreased CYP4F2-mediated omega-oxidation of hexadecanedioate relative to the biosynthesis or presence of eicosenoate, potentially indicating altered fatty acid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 variant decreases its enzymatic activity, potentially leading to an accumulation of substrates like hexadecanedioate relative to other fatty acids.1[1], 12[2] This altered fatty acid profile, coupled with CYP4F2's role in inflammation and vascular function, may contribute to the increased risk of coronary atherosclerosis.13[3], 14[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data