hexadecanedioate (c16-dc) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.132
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.260
Reference Allele:
C
-log10(P):
-36.465
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.037
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Fatty acid omega-oxidation.10[1], 11[2], 12[3]

Denominator Metabolite Explanation:

Denominator Pathway(s): Fatty acid biosynthesis, beta-oxidation.13[1], 14[2]

Ratio Explanation:

Ratio Interpretation: The ratio reflects CYP4F2 activity; decreased function likely reduces omega-oxidation of fatty acids (like palmitoleate) to dicarboxylic acids, altering the balance between the two.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 gene variant reduces the enzyme's efficiency in metabolizing fatty acids via omega-oxidation.1[1] This leads to an altered ratio of hexadecanedioate to its fatty acid precursors, a metabolic signature linked to increased risk for coronary atherosclerosis and ischaemic heart disease.15[2], 16[3], 17[4]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data