hexadecanedioate (c16-dc) to stearate (18:0)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.130
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.230
Reference Allele:
C
-log10(P):
-36.214
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.035
SE (Den):
0.017
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.11[1], 12[2]

Ratio Explanation:

This ratio reflects the activity of omega-oxidation (producing hexadecanedioate) relative to the general saturated fatty acid pool, a process influenced by CYP4F2.4[1], 5[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

CYP4F2 variants are associated with ischemic heart disease and atherosclerosis.13[1], 14[2], 15[3], 16[4] The enzyme's role in metabolizing lipids like arachidonic acid and its product hexadecanedioate's link to blood pressure likely drives this association.5[5], 7[6], 17[7], 18[8]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data