hexadecanedioate (c16-dc) to myristate (14:0)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs4149056

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.503
Position:
21331549
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
27.261
Reference Allele:
T
-log10(P):
-375.109
MAF:
0.155
Beta (Num):
0.516
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.013
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.128
Position:
15979744
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.562
Reference Allele:
C
-log10(P):
-39.041
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.033
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects omega-oxidation activity (producing hexadecanedioate) relative to the myristate pool, influenced by CYP4F2 function, which catalyzes the initial step of omega-oxidation.7[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

CYP4F2 variants are associated with altered fatty acid and eicosanoid metabolism, including the production of 20-HETE, which affects vascular tone.13[1], 14[2], 15[3] This altered signaling, reflected by the fatty acid ratio, is linked to an increased risk for coronary atherosclerosis and ischaemic heart disease.16[4], 17[5]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data