hexadecanedioate (c16-dc) to pentadecanoate (15:0)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.132
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.334
Reference Allele:
C
-log10(P):
-37.088
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.037
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.6[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, primarily from diet (dairy/ruminant fats).7[1]

Ratio Explanation:

The ratio of hexadecanedioate to pentadecanoate may reflect the rate of fatty acid omega-oxidation relative to the availability of an odd-chain fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 missense variant reduces the enzyme's function, potentially leading to altered fatty acid metabolism. This dysregulation, including changes in triglyceride levels, is associated with an increased risk for ischemic heart disease and coronary atherosclerosis.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data