hexadecanedioate (c16-dc) to margarate (17:0)

Numerator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.132
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.391
Reference Allele:
C
-log10(P):
-37.571
MAF:
0.296
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.037
SE (Den):
0.017
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.8[1]

Ratio Explanation:

Reduced CYP4F2 activity decreases hexadecanedioate (numerator) formation from its fatty acid precursor, lowering the ratio relative to margarate, which is not a direct substrate.5[1], 6[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 variant's association with coronary atherosclerosis is likely mediated by its reduced metabolism of pro-inflammatory leukotrienes, a known factor in atherosclerosis.9[1], 4[2], 10[3] The total bilirubin association is likely confounding due to the nearby SLCO1B1 gene, a primary bilirubin transporter.11[4], 12[5]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data