1-palmitoyl-gpi (16:0) to 1-stearoyl-gpi (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-gpi (16:0)
Metabolite Accession: GCST90199810
Name: 1-palmitoyl-gpi (16:0)
Hmdb Id: HMDB0061695
Super Pathway: NA
Sub Pathway: NA
Inchikey: UOXRPRZMAROFPH

Denominator Metabolite

Structure of 1-stearoyl-gpi (18:0)
Metabolite Accession: GCST90199659
Name: 1-stearoyl-gpi (18:0)
Hmdb Id: HMDB0240261
Super Pathway: NA
Sub Pathway: NA
Inchikey: LXUGKKVCSTYZFK

Associated Genomic Regions

Region: rs11668882

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.092
Position:
54675097
SE (Ratio):
0.010
Effect Allele:
C
Z-score (Ratio):
9.428
Reference Allele:
T
-log10(P):
-46.927
MAF:
0.437
Beta (Num):
0.073
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.019
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
TMC4 MBOAT7 LENG1 CNOT3 TSEN34

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis2[1]

Denominator Metabolite Explanation:

GPI anchor biosynthesis2[1]

Ratio Explanation:

This ratio indicates the relative abundance of GPI anchors with palmitoyl (16:0) versus stearoyl (18:0) acyl chains, reflecting lipid remodeling activity.3[1], 4[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered MBOAT7 activity likely changes the 1-palmitoyl-GPI to 1-stearoyl-GPI ratio.3[1], 2[2] Since alkaline phosphatase is a GPI-anchored protein6[3], 7[4], 8[5], this change could affect its function or localization, influencing ALP levels. GPI-anchored proteins are also implicated in platelet biology.9[6], 10[7]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data