indoleacetylglutamine to indoleacetate

Numerator Metabolite

Structure of indoleacetylglutamine
Metabolite Accession: GCST90199817
Name: indoleacetylglutamine
Hmdb Id: HMDB0013240
Super Pathway: NA
Sub Pathway: NA
Inchikey: DVJIJAYHBZALOJ

Denominator Metabolite

Structure of indoleacetate
Metabolite Accession: GCST90199683
Name: indoleacetate
Hmdb Id: HMDB0000197
Super Pathway: NA
Sub Pathway: NA
Inchikey: SEOVTRFCIGRIMH

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.234
Position:
151879761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
12.827
Reference Allele:
G
-log10(P):
-85.048
MAF:
0.335
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.070
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs2271060

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.300
Position:
20482623
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
16.106
Reference Allele:
G
-log10(P):
-132.712
MAF:
0.304
Beta (Num):
0.218
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.083
SE (Den):
0.017
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A AC137056.1 ACSM5 ACSM2B PDILT

Region: rs78303338

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.338
Position:
20854970
SE (Ratio):
0.037
Effect Allele:
T
Z-score (Ratio):
9.264
Reference Allele:
C
-log10(P):
-45.377
MAF:
0.059
Beta (Num):
0.220
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
-0.118
SE (Den):
0.033
No CNV overlap
rQTL cluster:
29
Reaction Distance:
NA
Closest Genes:
AC004381.6 ERI2 DCUN1D3 ACSM3 LYRM1

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan Metabolism

Denominator Metabolite Explanation:

Tryptophan Metabolism

Ratio Explanation:

The ratio reflects the conjugation of indoleacetate (from tryptophan metabolism) with glutamine, a detoxification reaction occurring in the liver.6[1], 7[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was provided, so no link can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data