indoleacetylglutamine to indolepropionate

Numerator Metabolite

Structure of indoleacetylglutamine
Metabolite Accession: GCST90199817
Name: indoleacetylglutamine
Hmdb Id: HMDB0013240
Super Pathway: NA
Sub Pathway: NA
Inchikey: DVJIJAYHBZALOJ

Denominator Metabolite

Structure of indolepropionate
Metabolite Accession: GCST90199686
Name: indolepropionate
Hmdb Id: HMDB0002302
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOLXRNDWAUTYKT

Associated Genomic Regions

Region: rs7186805

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.390
Position:
20477163
SE (Ratio):
0.027
Effect Allele:
C
Z-score (Ratio):
14.601
Reference Allele:
G
-log10(P):
-109.501
MAF:
0.303
Beta (Num):
0.216
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.174
SE (Den):
0.017
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A AC137056.1 ACSM5 PDILT ACSM2B

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan Metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Tryptophan Metabolism1[1], 5[2]

Ratio Explanation:

A higher ratio suggests a shift in tryptophan metabolism, favoring the host-driven indoleacetylglutamine pathway over the microbial indolepropionate pathway, potentially due to dysbiosis.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data