indoleacetylglutamine to indolebutyrate

Numerator Metabolite

Structure of indoleacetylglutamine
Metabolite Accession: GCST90199817
Name: indoleacetylglutamine
Hmdb Id: HMDB0013240
Super Pathway: NA
Sub Pathway: NA
Inchikey: DVJIJAYHBZALOJ

Denominator Metabolite

Structure of indolebutyrate
Metabolite Accession: GCST90199759
Name: indolebutyrate
Hmdb Id: HMDB0002096
Super Pathway: NA
Sub Pathway: NA
Inchikey: JTEDVYBZBROSJT

Associated Genomic Regions

Region: rs1827711

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.423
Position:
20482368
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
15.019
Reference Allele:
A
-log10(P):
-115.723
MAF:
0.303
Beta (Num):
0.217
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.205
SE (Den):
0.024
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A AC137056.1 ACSM5 ACSM2B PDILT

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Tryptophan metabolism8[1], 9[2]

Ratio Explanation:

The ratio may reflect alterations in tryptophan metabolism, where ACSM2A could potentially influence the balance between these two indole-containing molecules.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data