dihomo-linolenate (20:3n3 or n6) to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.360
Position:
61581764
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
17.744
Reference Allele:
T
-log10(P):
-160.524
MAF:
0.309
Beta (Num):
0.097
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.264
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, fatty acid biosynthesis.3[1], 1[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, phospholipid biosynthesis.1[1], 4[2]

Ratio Explanation:

This ratio directly reflects FADS1 delta-5 desaturase activity, representing the conversion of the substrate dihomo-linolenate to arachidonic acid, which is incorporated into the denominator.5[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters the ratio of pro- to anti-inflammatory fatty acids like arachidonic acid and dihomo-linolenate.6[1], 7[2], 8[3] This dysregulation of inflammatory mediators and lipid metabolism likely drives associated inflammatory and metabolic phenotypes like asthma, dermatitis, and lipid disorders.9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data