dihomo-linolenate (20:3n3 or n6) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.181
Position:
61567753
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
10.073
Reference Allele:
C
-log10(P):
-53.282
MAF:
0.302
Beta (Num):
0.094
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.086
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
12.0
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis1[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between fatty acid synthesis and degradation, where FADS1 activity influences dihomo-linolenate levels and SLC22A5-mediated carnitine transport is essential for fatty acid oxidation.1[1], 2[2], 7[3], 6[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and SLC22A5 alter the balance of pro-inflammatory and anti-inflammatory lipids and affect fatty acid oxidation, which can contribute to lipid metabolism disorders, inflammation seen in asthma and dermatitis, and influence cell proliferation in benign neoplasms.1[1], 9[2], 10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data