dihomo-linolenate (20:3n3 or n6) to 3-hydroxymyristate

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.169
Position:
61595564
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
10.918
Reference Allele:
C
-log10(P):
-62.222
MAF:
0.179
Beta (Num):
0.145
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.024
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, potential lipopolysaccharide biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio may reflect the balance between endogenous fatty acid synthesis and modification by FADS enzymes, versus potential incorporation of microbial-related fatty acids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 and FADS2 alters polyunsaturated fatty acid metabolism, which can influence inflammatory skin conditions like seborrhoeic dermatitis.1[1], 2[2], 8[3], 9[4] Altered lipid profiles are also associated with changes in blood cell parameters.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data