dihomo-linolenate (20:3n3 or n6) to 3-hydroxylaurate

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.124
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
8.948
Reference Allele:
G
-log10(P):
-42.460
MAF:
0.318
Beta (Num):
0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.105
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs968567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.169
Position:
61595564
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
10.064
Reference Allele:
C
-log10(P):
-53.191
MAF:
0.179
Beta (Num):
0.145
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.024
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation8[1], 9[2]

Ratio Explanation:

The ratio reflects the balance between fatty acid synthesis (dihomo-linolenate) and breakdown (3-hydroxylaurate), with genetic links to FADS1/FADS2 influencing fatty acid metabolism.1[1], 10[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid metabolism, influencing levels of inflammatory mediators.11[1] This dysregulation is linked to inflammatory skin conditions like seborrhoeic and infective dermatitis, and sinusitis, likely due to altered immune responses.11[2], 12[3] Blood lipid and cell count associations may also stem from these systemic metabolic changes.13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data