dihomo-linolenate (20:3n3 or n6) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174560

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.238
Position:
61581764
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
27.448
Reference Allele:
T
-log10(P):
-380.236
MAF:
0.309
Beta (Num):
0.097
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.141
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs11644601

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.084
Position:
15172118
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
9.506
Reference Allele:
T
-log10(P):
-47.666
MAF:
0.291
Beta (Num):
0.098
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.014
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 RRN3 NTAN1 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Eicosanoid synthesis5[1], 1[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Eicosanoid synthesis5[1], 8[2], 9[3]

Ratio Explanation:

The ratio of dihomo-linolenate to docosapentaenoate reflects the enzymatic efficiency of FADS1/FADS2 in converting omega-6 and omega-3 fatty acids, influencing inflammatory and metabolic pathways.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the balance of pro- and anti-inflammatory polyunsaturated fatty acids.12[1] This dysregulation of lipid metabolism is linked to an increased risk for inflammatory conditions like asthma and phlebitis, and metabolic disorders such as cholelithiasis and dyslipidemias.13[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data