dihomo-linolenate (20:3n3 or n6) to myristoleate (14:1n5)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.135
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
9.144
Reference Allele:
G
-log10(P):
-44.259
MAF:
0.176
Beta (Num):
0.038
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.097
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs968567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.145
Position:
61595564
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
9.915
Reference Allele:
C
-log10(P):
-51.683
MAF:
0.179
Beta (Num):
0.145
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-1.86e-04
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis

Denominator Metabolite Explanation:

Monounsaturated fatty acid (MUFA) biosynthesis

Ratio Explanation:

The ratio of dihomo-linolenate to myristoleate reflects the balance between polyunsaturated and monounsaturated fatty acid synthesis, which is influenced by FADS and SCD activity.1[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster (FADS1/FADS2) alter desaturase activity, affecting the balance of PUFAs like dihomo-linolenate.1[1], 4[2] This dysregulation of fatty acid metabolism is strongly associated with altered lipid profiles (cholesterol, triglycerides) and an increased risk of coronary atherosclerosis.5[3], 2[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data