dihomo-linolenate (20:3n3 or n6) to stearidonate (18:4n3)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.205
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
17.165
Reference Allele:
A
-log10(P):
-150.391
MAF:
0.346
Beta (Num):
0.087
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
6.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the activity of FADS desaturase enzymes which regulate the balance of different polyunsaturated fatty acids within their shared biosynthetic pathway.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, influencing lipid profiles and inflammatory responses. This alteration is associated with metabolic phenotypes like cholelithiasis, type 2 diabetes, and hypercholesterolemia, which are linked to disruptions in lipid and inflammatory pathways.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data