dihomo-linolenate (20:3n3 or n6) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
0.150
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.613
Reference Allele:
G
-log10(P):
-48.705
MAF:
0.176
Beta (Num):
0.038
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1]

Ratio Explanation:

This ratio likely reflects SCD activity, which regulates the overall fatty acid pool, thus indirectly altering the balance between dihomo-linolenate and 5-dodecenoate levels.5[1], 1[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants impacting SCD activity alter fatty acid profiles, as reflected by the ratio. This dysregulation of lipid metabolism is a known risk factor for associated cardiometabolic phenotypes like atherosclerosis and hypercholesterolaemia.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data