dihomo-linolenate (20:3n3 or n6) to (16 or 17)-methylstearate (a19:0 or i19:0)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Associated Genomic Regions

Region: rs968567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.153
Position:
61595564
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
9.629
Reference Allele:
C
-log10(P):
-48.858
MAF:
0.179
Beta (Num):
0.145
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.008
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Branched-chain fatty acid metabolism7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the balance between endogenous synthesis of long-chain polyunsaturated fatty acids by FADS enzymes and the levels of exogenously derived branched-chain fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter fatty acid metabolism, influencing levels of dihomo-linolenate.4[1], 10[2], 11[3] This altered lipid profile is associated with inflammatory skin conditions like seborrhoeic and infective dermatitis12[4], 13[5], 14[6] and systemic effects on blood lipids and cell counts.15[7], 16[8], 17[9], 18[10]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data