dihomo-linolenate (20:3n3 or n6) to cis-4-decenoate (10:1n6)*

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.428
Position:
151879761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
26.946
Reference Allele:
G
-log10(P):
-366.558
MAF:
0.318
Beta (Num):
0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.409
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid synthesis6[1]

Ratio Explanation:

The ratio may reflect the balance between the synthesis of a longer-chain polyunsaturated fatty acid and a shorter-chain monounsaturated fatty acid, potentially influenced by THEM4's role in fatty acid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype was provided in the input data, so a link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data