dihomo-linolenate (20:3n3 or n6) to n-oleoyltaurine

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.251
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-14.540
Reference Allele:
C
-log10(P):
-108.616
MAF:
0.209
Beta (Num):
-0.012
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, Biosynthesis of unsaturated fatty acids.3[1]

Denominator Metabolite Explanation:

N-acyltaurine biosynthesis, Fatty acid amide degradation.4[1], 5[2]

Ratio Explanation:

A lower ratio may indicate reduced FAAH function, leading to the accumulation of N-oleoyltaurine, an FAAH substrate, relative to dihomo-linolenate.6[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype is provided, so a direct link cannot be established. Reduced FAAH activity, potentially from a missense variant, would decrease the degradation of N-oleoyltaurine, altering the ratio.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data