dihomo-linolenate (20:3n3 or n6) to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.258
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
12.404
Reference Allele:
T
-log10(P):
-79.679
MAF:
0.309
Beta (Num):
0.097
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.162
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Phospholipid and fatty acid metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects the activity of FADS1, where a higher ratio indicates lower enzyme efficiency in converting the precursor (dihomo-linolenate) to its product (arachidonic acid).8[1], 9[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity increases the dihomo-linolenate to arachidonic acid (AA) ratio, altering the balance of pro- and anti-inflammatory eicosanoids, which is linked to inflammatory conditions like asthma, dermatitis, and sinusitis, and also affects lipid metabolism.2[1], 10[2], 11[3], 4[4]

Phenotype Driver:

Metabolite-centric:dihomo-linolenate (20:3n3 or n6)/1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data