dihomo-linolenate (20:3n3 or n6) to arachidonoylcholine

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.293
Position:
61581764
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
13.249
Reference Allele:
T
-log10(P):
-90.584
MAF:
0.309
Beta (Num):
0.097
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.197
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Choline metabolism, Fatty acid metabolism

Ratio Explanation:

The ratio reflects FADS1 activity converting dihomo-linolenate to arachidonate, the precursor of arachidonoylcholine, linking fatty acid and choline metabolism.1[1], 3[2], 4[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence the conversion of dihomo-linolenate to arachidonic acid, the precursor for arachidonoylcholine.1[1], 5[2] This altered ratio impacts inflammatory and lipid pathways, contributing to phenotypes like asthma, dermatitis, and dyslipidaemias by modulating the balance of pro- and anti-inflammatory eicosanoids and cholinergic signaling.6[3], 7[4], 4[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data