dihomo-linolenate (20:3n3 or n6) to hexadecadienoate (16:2n6)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.105
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
7.664
Reference Allele:
G
-log10(P):
-31.648
MAF:
0.176
Beta (Num):
0.038
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.068
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs968567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.143
Position:
61595564
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
10.472
Reference Allele:
C
-log10(P):
-57.417
MAF:
0.179
Beta (Num):
0.145
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.002
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs12928099

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.110
Position:
15150505
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
9.558
Reference Allele:
C
-log10(P):
-48.173
MAF:
0.291
Beta (Num):
0.100
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects the conversion efficiency of fatty acid precursors, where FADS2 is involved in the metabolic cascade that includes both metabolites.1[1], 9[2], 10[3], 4[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity, influenced by genetic factors, can alter the balance of polyunsaturated fatty acids, which is associated with dyslipidemia and an increased risk of coronary atherosclerosis and myocardial infarction.11[1], 12[2], 13[3], 14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data