dihomo-linolenate (20:3n3 or n6) to n-stearoyl-sphingadienine (d18:2/18:0)*

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of n-stearoyl-sphingadienine (d18:2/18:0)*
Metabolite Accession: GCST90200111
Name: n-stearoyl-sphingadienine (d18:2/18:0)*
Hmdb Id: HMDB0240362
Super Pathway: NA
Sub Pathway: NA
Inchikey: LBBFOWQGVUEADU

Associated Genomic Regions

Region: rs61896141

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.239
Position:
61556039
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
9.469
Reference Allele:
A
-log10(P):
-47.312
MAF:
0.179
Beta (Num):
0.149
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.091
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Sphingolipid metabolism

Ratio Explanation:

The ratio of dihomo-linolenate to n-stearoyl-sphingadienine likely reflects the interplay between fatty acid desaturation and sphingolipid synthesis, where FADS2 activity influences the availability of precursors for both pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS2 activity, which has a significant MR on the ratio, influences the balance of fatty acids, potentially affecting inflammatory processes and cell membrane composition, contributing to skin conditions like seborrhoeic and infective dermatitis, as well as sinusitis, and impacting various blood lipid and cell count parameters.

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data