dihomo-linolenate (20:3n3 or n6) to nisinate (24:6n3)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.241
Position:
61593816
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
12.092
Reference Allele:
C
-log10(P):
-75.835
MAF:
0.339
Beta (Num):
0.084
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.156
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis6[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis7[1]

Ratio Explanation:

The ratio reflects the efficiency of desaturation and elongation in the polyunsaturated fatty acid pathway, which is regulated by FADS1 and FADS2 activity.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the balance of pro- and anti-inflammatory lipids, reflected in the dihomo-linolenate to nisinate ratio, which is associated with inflammatory conditions like IBD and asthma, and cardiovascular phenotypes like hypercholesterolemia and valvular heart disease.8[1], 9[2]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data