dihomo-linolenate (20:3n3 or n6) to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.289
Position:
61571348
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
14.768
Reference Allele:
C
-log10(P):
-111.972
MAF:
0.309
Beta (Num):
0.094
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.195
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects the efficiency of fatty acid elongation and desaturation, processes catalyzed by FADS enzymes, in converting dihomo-linolenate to downstream polyunsaturated fatty acids.9[1], 10[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Gene-centric:FADS1

Phenotype Driver:

FADS1/FADS2 genetic variants alter polyunsaturated fatty acid metabolism, influencing lipid profiles and inflammatory responses.12[1], 13[2], 14[3], 15[4] This dysregulation is linked to an increased risk for lipid-related disorders like hypercholesterolemia and cholelithiasis, and inflammatory conditions such as asthma.16[5], 17[6], 18[7], 19[8]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data