dihomo-linolenate (20:3n3 or n6) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.142
Position:
151879761
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
11.405
Reference Allele:
G
-log10(P):
-67.703
MAF:
0.318
Beta (Num):
0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs61896141

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.166
Position:
61556039
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
10.947
Reference Allele:
A
-log10(P):
-62.541
MAF:
0.179
Beta (Num):
0.149
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.017
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs12928099

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.106
Position:
15150505
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
8.372
Reference Allele:
C
-log10(P):
-37.408
MAF:
0.291
Beta (Num):
0.100
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.006
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.1[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.

Ratio Explanation:

The ratio of dihomo-linolenate to tetradecadienoate may reflect the rate of long-chain polyunsaturated fatty acid synthesis, a process governed by FADS enzymes.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1 alter its enzymatic activity, impacting the balance of pro- and anti-inflammatory PUFA-derived mediators.7[1], 8[2] This dysregulation of inflammation is a key factor in the pathogenesis of inflammatory skin diseases like dermatitis and sinusitis.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data