dihomo-linolenate (20:3n3 or n6) to nonadecanoate (19:0)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.149
Position:
61595564
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
9.665
Reference Allele:
C
-log10(P):
-49.213
MAF:
0.179
Beta (Num):
0.145
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.004
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

Exogenous origin, primarily from diet.5[1]

Ratio Explanation:

The ratio reflects FADS desaturase activity, where dihomo-linolenate is a precursor and its levels are influenced by FADS1/2, relative to an exogenous fatty acid.1[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants impact LC-PUFA metabolism, which is linked to inflammatory skin conditions like seborrhoeic and infective dermatitis, and lipid profiles.6[1], 7[2], 8[3], 9[4] Altered FADS activity influences the balance of pro- and anti-inflammatory lipid mediators, potentially driving the pathogenesis of these inflammatory skin diseases and affecting systemic lipid levels.10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data