1-linoleoyl-gpi (18:2)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174548

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.424
Position:
61571348
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
19.608
Reference Allele:
C
-log10(P):
-195.441
MAF:
0.309
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.263
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs8736

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.324
Position:
54677189
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
15.658
Reference Allele:
C
-log10(P):
-125.563
MAF:
0.435
Beta (Num):
0.150
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

GPI-anchor biosynthesis, Linoleate metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

GPI-anchor biosynthesis, Arachidonic acid metabolism, Phospholipid remodeling.3[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio reflects the efficiency of incorporating arachidonic acid into GPI anchors, a process where MBOAT7 acylates lysophosphatidylinositol, and FADS1 synthesizes arachidonic acid.12[1], 3[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 function alters arachidonic acid levels in phosphatidylinositols, impacting precursors for inflammatory eicosanoids.13[1], 14[2], 5[3] This dysregulation of lipid mediators contributes to inflammatory conditions like asthma and dermatitis, and disorders of lipoprotein metabolism.15[4], 16[5], 17[6]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data