1-linoleoyl-gpi (18:2)* to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.251
Position:
61569830
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
12.738
Reference Allele:
C
-log10(P):
-83.910
MAF:
0.340
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.085
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Phospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis, omega-3 fatty acid pathway.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of 1-linoleoyl-GPI (a linoleic acid-containing lipid) to DHA reflects FADS enzyme activity, where lower activity increases precursors and decreases long-chain products.9[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of omega-6 and omega-3 fatty acids, impacting inflammation and lipid metabolism, which contributes to phenotypes like dyslipidemia and type 2 diabetes.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data