1-linoleoyl-gpi (18:2)* to 1-stearoyl-gpi (18:0)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-stearoyl-gpi (18:0)
Metabolite Accession: GCST90199659
Name: 1-stearoyl-gpi (18:0)
Hmdb Id: HMDB0240261
Super Pathway: NA
Sub Pathway: NA
Inchikey: LXUGKKVCSTYZFK

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.180
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
11.973
Reference Allele:
A
-log10(P):
-74.388
MAF:
0.344
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.016
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs11668882

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.169
Position:
54675097
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
11.545
Reference Allele:
T
-log10(P):
-69.328
MAF:
0.437
Beta (Num):
0.150
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.019
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
TMC4 MBOAT7 LENG1 CNOT3 TSEN34

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.9[1], 6[2]

Ratio Explanation:

The ratio reflects the desaturation of stearoyl-GPI to linoleoyl-GPI, a key step in fatty acid metabolism likely influenced by FADS1/FADS2 activity.1[1], 2[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity may decrease the conversion of stearic acid to linoleic acid, altering membrane composition and inflammatory responses, potentially contributing to gallstone formation (Cholelithiasis) and inflammatory conditions like phlebitis and IBD.1[1], 2[2], 11[3], 3[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data