1-linoleoyl-gpi (18:2)* to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.383
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
18.936
Reference Allele:
T
-log10(P):
-182.456
MAF:
0.347
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.221
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Saturated fatty acid synthesis.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects FADS1 desaturase activity, contrasting a polyunsaturated glycerophosphoinositol (1-linoleoyl-GPI) with a saturated glycerophosphocholine (1,2-dipalmitoyl-GPC), indicating the balance of fatty acid pools.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters PUFA synthesis, reflected by the ratio.12[1] This dysregulation of PUFAs, which are precursors to inflammatory mediators, contributes to phenotypes like asthma, hypercholesterolemia, and cholelithiasis by affecting inflammation and lipid metabolism.13[2], 14[3], 15[4], 16[5], 17[6], 18[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data