1-linoleoyl-gpi (18:2)* to adrenate (22:4n6)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.348
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
16.965
Reference Allele:
C
-log10(P):
-146.962
MAF:
0.340
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.183
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism.2[1], 3[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1]

Ratio Explanation:

This ratio reflects the activity of the FADS-catalyzed conversion of linoleic acid (a precursor to 1-linoleoyl-GPI) to adrenate, a key step in fatty acid metabolism.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a higher ratio, alters lipid profiles, including triglycerides and HDL/LDL cholesterol, which are known risk factors for cholelithiasis and other metabolic disorders.5[1], 6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data