1-linoleoyl-gpi (18:2)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.435
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
21.926
Reference Allele:
A
-log10(P):
-243.689
MAF:
0.344
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid metabolism, Glycerophosphoinositol metabolism4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Monoacylglycerol metabolism, Endocannabinoid signaling7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between glycerophosphoinositol and endocannabinoid pathways, where higher FADS1/2 activity favors the formation of arachidonic acid (a precursor to 1-arachidonylglycerol).

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 alter the efficiency of polyunsaturated fatty acid synthesis.3[1], 10[2] This impacts the levels of arachidonic acid, a key component of 1-arachidonylglycerol and a precursor for inflammatory mediators, thus influencing the risk for inflammatory and metabolic disorders like cholelithiasis and type 2 diabetes.11[3], 2[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data