1-linoleoyl-gpi (18:2)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.253
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
11.994
Reference Allele:
T
-log10(P):
-74.641
MAF:
0.308
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol signaling system.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.5[1], 6[2]

Ratio Explanation:

This ratio may reflect the rate of desaturation of fatty acids, where higher FADS1 activity could influence the balance between different glycerophospholipid species.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1 activity, influenced by genetic factors, affects the balance of polyunsaturated fatty acids.1[1], 7[2] This dysregulation is linked to inflammatory and metabolic phenotypes like asthma, cholelithiasis, and hypercholesterolemia, likely through modulation of inflammatory lipid mediators and cholesterol metabolism.8[3], 9[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data