1-linoleoyl-gpi (18:2)* to 2-palmitoyl-gpc (16:0)*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 2-palmitoyl-gpc (16:0)*
Metabolite Accession: GCST90199789
Name: 2-palmitoyl-gpc (16:0)*
Hmdb Id: HMDB0061702
Super Pathway: NA
Sub Pathway: NA
Inchikey: NEGQHKSYEYVFTD

Associated Genomic Regions

Region: rs174580

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.214
Position:
61606642
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
11.937
Reference Allele:
A
-log10(P):
-73.960
MAF:
0.351
Beta (Num):
0.162
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.052
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism, Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Phosphatidylcholine biosynthesis, Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the balance between a lysophosphatidylinositol and a lysophosphatidylcholine, influenced by FADS enzymes that modify fatty acid chains available for phospholipid synthesis.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism, which is linked to changes in blood lipids like cholesterol and triglycerides.7[1], 8[2], 9[3], 10[4] This dyslipidemia, particularly altered cholesterol levels, is a major risk factor for cholelithiasis (gallstones), a frequently associated phenotype.11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data