1-linoleoyl-gpi (18:2)* to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
12
Beta (Ratio):
0.274
Position:
21343833
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
9.558
Reference Allele:
A
-log10(P):
-48.168
MAF:
0.156
Beta (Num):
0.156
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Lysolipid.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.8[1], 9[2]

Ratio Explanation:

The ratio likely reflects altered SLCO1B1-mediated transport of androstenediol monosulfate, potentially influencing glycerophospholipid metabolism through indirect effects on cellular processes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can increase circulating levels of its substrates, including bilirubin and androstenediol monosulfate.10[1], 11[2], 12[3] This may directly impact TBil, MCH, and MCV, and altered steroid and lipid metabolism may contribute to coronary atherosclerosis, and changes in TG, TP, and UA.13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data