1-linoleoyl-gpi (18:2)* to 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Metabolite Accession: GCST90200046
Name: 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Hmdb Id: HMDB0008057
Super Pathway: NA
Sub Pathway: NA
Inchikey: FAUYAENFVCNTAL

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.413
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
17.717
Reference Allele:
C
-log10(P):
-160.055
MAF:
0.340
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.247
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio reflects polyunsaturated fatty acid (PUFA) metabolism, comparing a linoleic acid (18:2)-containing GPI anchor to a phosphatidylcholine with a docosahexaenoic acid (22:6).7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter desaturase activity, impacting the balance of omega-6 and omega-3 fatty acids.1[1], 2[2] This dysregulation is linked to inflammatory conditions like dermatitis and metabolic phenotypes such as cholelithiasis, which is strongly associated with FADS polymorphisms and altered cholesterol metabolism.9[3], 10[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data