1-linoleoyl-gpi (18:2)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.303
Position:
61592362
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
13.483
Reference Allele:
A
-log10(P):
-93.726
MAF:
0.345
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.140
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.9[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Denominator Metabolite Explanation:

Glycerophosphoethanolamine metabolism, fatty acid metabolism.15[1], 16[2], 17[3], 18[4], 19[5], 20[6]

Ratio Explanation:

The ratio reflects the relative abundance of a linoleic acid-containing GPI anchor to a phospholipid containing arachidonic acid, influenced by FADS desaturase activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, alters polyunsaturated fatty acid metabolism. This is linked to inflammatory and metabolic disorders like asthma and hypercholesterolemia, as FADS enzymes are crucial for synthesizing signaling molecules that regulate these processes.3[1], 21[2], 22[3], 23[4], 24[5], 25[6], 26[7], 27[8], 28[9], 29[10], 30[11], 31[12], 32[13], 33[14]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data