1-linoleoyl-gpi (18:2)* to 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.273
Position:
61557803
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
12.556
Reference Allele:
T
-log10(P):
-81.593
MAF:
0.347
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis

Denominator Metabolite Explanation:

Ether lipid metabolism

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, contrasting a linoleic acid (18:2)-containing GPI lipid with a plasmalogen, indicating altered fatty acid flux into different lipid backbones.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters desaturase activity, impacting polyunsaturated fatty acid levels.3[1] This dysregulation, reflected by the ratio, likely influences inflammatory pathways and lipid metabolism, contributing to phenotypes like inflammatory bowel disease4[2], 5[3], asthma6[4], 7[5], 8[6], and hypercholesterolemia.3[7], 9[8]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data