1-linoleoyl-gpi (18:2)* to 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.331
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
15.422
Reference Allele:
T
-log10(P):
-121.879
MAF:
0.347
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.168
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis4[1]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis5[1]

Ratio Explanation:

This ratio compares a linoleic acid-containing GPI anchor to a saturated plasmalogen, likely reflecting FADS enzyme activity on the availability of polyunsaturated versus saturated fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of polyunsaturated fatty acids, impacting inflammation and lipid levels.6[1], 7[2], 8[3] This is strongly associated with dyslipidemias and cholelithiasis, likely through effects on lipoprotein metabolism and bile acid composition.8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data